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KMID : 0363320120330040387
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Journal of Korean Oriental Internal Medicine
2012 Volume.33 No. 4 p.387 ~ p.404
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Anticancer and Related Immunomodulatory Effects of Kwibi-tang on Non-small Cell Lung Carcinoma, NCI-H520, Xenograft Mice
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Son Ji-Young
Choi Hae-Yun
Kim Jong-Dae
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Abstract
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Objectives : This study was to observe anticancer and related immunomodulatory effects of Kwibi-tang extracts (KBTe)
on non-small cell lung carcinoma (squamous epithelial carcinoma), NCI-H520, xenograft Balb/c nu-nu nude mice.
Methods : Three different dosages of KBTe, 50, 100 and 200 mg/kg were orally administered once a day for 42 days from
11 days after tumor cell inoculation. Six groups, each of 8 mice per group were used in the present study. Changes in body weight, tumor volume and weight, lymphatic organs (spleen and popliteal lymph node), serum interferon (IFN)-γ levels, splenocytes NK cell activity and peritoneal macrophage activities, splenic tumor necrosis factor (TNF)-α, interleukin (IL)-1β and IL-10 contents were observed with tumor mass and lymphatic organ histopathology to detect anticancer and immunomodulatory effects. The results were compared with a potent cytotoxic anticancer agent, 5-FU (5-Fluorouracil) 30mg/kg, intraperitoneal treatment (3-day intervals for 42 days, the optimal effective treatment regimes already confirmed).
Results & Conclusions : This study suggest that over 50 mg/kg of KBTe showed favorable anticancer effects on the
NCI-H520 cell xenograft with immunomodulatory effects. Although relatively lower anticancer effects were observed in KBTe 200 mg/kg treated mice as compared with 5-FU 30 mg/kg treated mice, no meaningful favorable immunomodulatory effects were observed after 5-FU treatment in the present study.
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KEYWORD
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Kwibi-tang (Guipi-tang) extracts, anticancer effects, immunomodulatory effects, non-small cell lung carcinoma, Balb/c nu-nu nude mice
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